Kailin Xu

Guangdong University of Technology

“One-Hundred Young Talents”

Education and Research Experience

Ph.D.:Pharmaceutical engineering2014.09-2017.06

College of Chemical Engineering, Sichuan University, Chengdu 610065, China

Supervisor:Professor Gang Zhao

Master:Pharmaceutical engineering2011.09-2014.06

College of Chemical Engineering, Sichuan University, Chengdu 610065, China

Supervisor:Professor Bing Liang

Bachelor:Pharmaceutical engineering2007.09-2011.06

College of Chemical and Material Science Engineering, Huaihua University

Work Experience

“One-Hundred Young Talents”2017.07-Now

Guangdong University of Technology

Visiting Scholar2018.03-2019.03.

Li Ka Shing School of Medicine, University of Hong Kong

Research Interest

·Diversity of solid forms of drugs, including polymorphs, pseudo polymorphs (solvates and hydrates), salts, co-crystals, and amorphous solids

·Pharmaceutical process monitoring

·Drugcrystallography

Published Papers

1.Kailin Xu, Menglin Qian, Jiewu Leng, Jie Bai, Qinglan Li, Zihong Liu, Shijuan Zhong and Suqing Zhao. Direct salinization of trelagliptin from solid forms by mechanochemistry and its mechanism of salts forming [J]. CrystEngComm, 2020, DOI: 10.1039/D0CE00984A.

2.Xu Kailin, Zheng Shoujun, Zhai Yuanming,et al. Two solid forms of tauroursodeoxycholic acid and the effects of milling and storage temperature on solid-state transformations [J].International journal of pharmaceutics, 2020, doi.org/10.1016/j.xphs.2020.10.063.

3. Jiewu Leng, Guolei Ruan, Pingyu Jiang,Kailin Xu*, Qiang Liu, Xueliang Zhou, and Chao Liu. Blockchain-empowered sustainable manufacturing and product lifecycle management in Industry 4.0: A survey. Renewable & Sustainable Energy Reviews. 2020, 132, 110112.

4. Jiewu Leng, Pingyu Jiang,Kailin Xu*, Qiang Liu, J. Leon Zhao, Yiyang Bian, Rui Shi. Makerchain: A blockchain with chemical signature for self-organizing process in social manufacturing [J]. Journal of Cleaner Production, 2019, 234, 767-778.

5.Xu Kailin, Zheng Shoujun, Zhai Yuanming,et al. Two solid forms of tauroursodeoxycholic acid and the effects of milling and storage temperature on solid-state transformations [J].International journal of pharmaceutics, 2015, 486(1),185-194.

6.Xu Kailin, Xiong Xinnuo, Li Shanshan,et al. New polymorph of glipizide with enhanced properties obtained using environmentally friendly methods[J].CrystEngComm, 2016, 18, 4508–4512.

7.Xu Kailin, Liang Bin, Li Yanfang,et al. Injection-ultrasound-assisted emulsification microextraction based on using low-density organic solvent followed by high-performance liquid chromatography for the determination of pyrethroids in water samples[J].Analyst, 2013, 138(4),1262-1270.

8.Xu Kailin, Xiong Xinnuo, Zhai Yuanming, et al. Effect of milling conditions on solid-state amorphization of glipizide, and characterization and stability of solid forms [J].Journal of Pharmaceutical and Biomedical Analysis, 2016, 129: 367-377.

9.Xu Kailin, Zheng Shoujun, Guo Liuqi, et al. Four solid forms of tauroursodeoxycholic acid and solid-state transformations: effects of temperature and milling [J].RSC Advances, 2015, 5(117),96392-96403.

10.Xu Kailin, Xiong Xinnuo, Guo Liuqi,et al. An Investigation into the Polymorphism and Crystallization of Levetiracetam and the Stability of its Solid Form [J].Journal of pharmaceutical sciences, 2015, 104(12),4123-4131.

11.Xu Kailin, Liang Bin, Wu Xiaoqing, et al. X-ray powder diffraction data for levetiracetam [J].Powder Diffraction, 2014, 29(01),51-52.

12. Xiao Yin,Xu Kailin, Wang Qing, et al. Synthesis, structure, and calf-thymus DNA binding of ternary fleroxacin–Cu (II) complexes[J].RSC Advances, 2016, 6(83): 80286-80295.

13. Li Zhenzhen,Xu Kailin, Liang Bin, et al. Determination of trace tetracyclines in surface water by aluminum hydroxide coprecipitation coupled with high-performance liquid chromatography [J].Analytical Methods, 2013, 5(14),3516-3522.

14. Cheng Yuan,Xu Kailin, Li Hui,et al. Preparation of Urea-Imprinted Cross-Linked Chitosan and Its Adsorption Behavior [J].Analytical Letters, 2014, 47(6),1063-1078.

15. Li Xiangling,Xu Kailin, Li Hui,et al. Qualitative analysis of chiral alanine by UV-visible-shortwave near infrared diffuse reflectance spectroscopy combined with chemometrics [J].RSC Advances, 2016, 6(10),8395-8405.

Research Project

·Basic and Applied Basic Research Foundation of Guangdong Province, 2020,100000 RMB,No. 2020A1515010952,Principal Investigator

·Guangdong University of Technology, “One-Hundred Young Talents”,2017,100000 RMB,Principal Investigator

teaching courses

·Pharmaceutical Process Safety and Environmental Protection

·Drug Synthesis Reaction

·Pharmaceutical Engineering Experiments