Name：Han Yali，Place of birth: Beijing

WorkCollege: College of BiomedicineinGuangdong University of Technology

Supervisor Category:Ph.D.Supervisor, Master'sSupervisor

Research Direction: Biochemical Drugs; Genetic Engineering Drugs;

Contact:Tel: 13620418957, Email:ylhan57@126.com

Ph.D. Admissions College: College of Biomedicine

Education Experience:Shereceived bachelor in Animal Physiology from Inner Mongolia University 1982,andreceived master degree and PhD in biochemistry and molecular biology from Shanxi Normal Universityin 1994 and 1997 respectively.

Work Experience：During 1999 and 2005, She was theheadof the Biology Department and the leader in Biochemistry and Molecular Biology in Shantou University. Since 2005and 2012, shehas beenaprofessor (Level 3)andwas the director Department of Food Science and Bioengineeringand the leader in the direction of biochemicalinGuangdong University of Technology.

Achievements in Scientific Research:

Her researchfocuses on antithrombotic, anti-cancer and anti-bacterial effects and mechanism of active substances and bioactive proteins of traditional Chinese medicine. It includesbasic and applied studies on cell culture,apoptosis,telomerase detection,biochemical immune analysis, and gene expressionandregulation of active protein.She has published over 90 research papers in refereed international journals and conferences (10 more indexed by SCI and 5 indexed by EI). She also published two books and obtained four patents.

She has completed more than 10 scientific research projects, including three the National Natural Science Foundation and two provincial natural scienceFoundation.

She has been successfully supervised more than 10 PhD students, 30 master students, and 3 post-doc.

Paper(In recent years)

1.Fan Peng，Yali Han*。Drowning Diagnosis by Detecting Diatoms rbcL Genes with PCR-Capillary Electrophoresis。Nanoscience and Nanotechnology Letters。2018，Vol. 10, 138–144。

2.Zhi—li ZHAO，Ming—zhu PAN，Yali HAN*。Antioxidant Activities of Crude Phlorotannins from Sargassum。J Hua zhong Univ Sci Technol,2016,36(3):449-455.

3.Quyi Xu, Yali Han*。Comparison of Digestion Methods Complied with Two Nanofiltration Membranes on the Efficiency of Diatoms Recovery. Journal of Nanoscience and Nanotechnology, 2016, Vol. 16, 7129–7133.

4.Ding-hong，Yali Han*。Effects of tachyplesin I on human U251 glioma stem cells。MOLECULAR MEDICINE REPORTS，2015，2015, 11(4):2953-8。

5.Huang, Mingxing，Ye, Yun，Han, Yali*，Purification of a Trypsin-Like Enzyme and Cloning of Its Gene from Chinese Ground Beetle (Eupolyphaga sinensis)，Journal of Food Biochemistry，2014，38（3）：316-327。

6.Huang, Ming Xing，Han, Ya Li*，Ye, Yun，Chen Ya Xiong，Partial Purification and Characterization of Fibrinolytic Enzymes from Yellow Mealworm，International Journal of Peptide Research and Therapeutics，2012，18（2）：153-161。

7.Ye yun, Han Yali* Cloning and Analysis of Trypsin-like Serine Protease cDNA of Yellow Mealworm(Tenebrio molitor)Larvae, Chinese J0urnal of Biochemistry and Molecular Biology,2012,（02）：169-176。

8.Tao, Zhihua，Han, Ya Li*，A simple and rapid method for histamine analysis in fish and fishery productsby TLC determination，Food Control，2011，（22）：1154-1157。

9.Li sui-jing, Han, Ya Li *。Studies on the Purification, Infrared Spectroscopic Analysis and Antiangiogenesis Effects of Fibrinolyric Protein(EFP) from Eupolyphage sinesis Walker. Chemical Journal of Chinese Universities, 2009, 30(10): 1998-2002.

10.Liu Guangming，Han, Ya Li (*)，Applicability of a rapid method based on immunomagnetic capture-fluorescent PCR assay for Campylobacter jejuni，Food Control，2006，（17）：527-532。

11.Chen Zhan-guang, Han, Ya Li *，Micro-determination of nucleic acids with a simple probe manganesechloride based on the fine enhanced resonance light scattering，Spectrochimica Acta Part A，2007，68：263-268。

12.Huang Ming-xing,Han, Ya Li *，Partial Purification and Characterizationof Fibrinolytic Enzymes from YellowMealworm，International Journal of Peptide，2012，18（2）：153-161

13.Xiong xing-dong，Han ya-li*.Effects of tachyplesin I on human U251 gliomastem cells，MOLECULAR MEDICINE REPORTS，2014，3892（10）：1-6。

14.Xiong xing-dong，Han ya-li*. Identification of differentially expressed proteins betweenhuman esophageal immortalized and carcinomatous celllines bytwo-dimensional electrophoresis andMALDI-TOFmassspectrometry，World Journal of Gastroenterology，2002，8（5）：777-781。

15.Xiong xing-dong，Han ya-li*，Separation and identification of differentially expressed nuclearmatrix proteins between human esophageal immortalized andcarcinomatous cell lines，World Journal of Gastroenterology，2003，9（10）：2143-2148。

16.Han Ya-li,Lin Fei-fan. Cloning of Tenebrio Fibrinolyric Proteins gene and Expression in Pichia pastoris and Biological Activities Assay. Journal University of Technology，2017，34（1）。

17.Zhang Wei-li,Han Ya-li*, The Extraction Process of Pinus Massoniana Optimized by Response Surface,Journal University of Technology，2013，30（1）。

18.Zhao Zhi-li，Han Yali*. Proliferation of NCI-H23 Promoted by ERαthrough Notch1 Signaling Pathway, Journal University of Technology，2016, 33(3):88-92

19.Liu Hong，Tan Yan,Han Yali*。Self-assembled NIRF/MRI Dual-modality Contrast Agents for Rat Bone Stem Cell(RBMSC) Tracking.Journal University of Technology，2016,33(4):62-68

20.Mai Bai-sheng, Han Ya-li*。Diagnosis of drowing by detecting gyrB and 16SrRNA genes of Aeromonas hydrophila using PCR-capillary electrophosis.Journal of Southern Medical University，2016, 36(11): 1550-1554

21.Lin Fei-fan，Han Ya-li*。Bioinformatic Analysis the Main Characteristics and Structure of the Gene Encoding CYP2E1 Protein，Journal University of Technology，2015，32（1）：16-19。

22.Lv Ya,Han Ya-li. Antioxidant Activities of Extravcts from Momordica Charantia L Journal University of Technology，2014，（4）：132-136。

23.Han Ya-li,Li Zhang-wei. Purification and Biochemical Character of a Fibrinolytic Protein from Eupolyphaga sinensis,Chinese Journal of Biotechnology,2006,22(4):639-643.

24.Zhang Min, Han Ya-li*，Extraction of Tatol Falconoids from Mikania Micrantha and Study of Antibacterial Activities，Journal University of Technology，2014,（2）：144-149。

25.Chen Bing,Han Ya-li*,Inhibitory Effect of Protein Of Eupolyphaga sinensis Walker and Medicated Serum on HepG-2 and MCF-7 Cell line, Lishizhen Medicine and Materia Medica Research，2011，（06）：1295-1297。

26.Cao Fu-chun, Han Ya-li*，Effect of Eupolyphaga Fibrinolytic Protein on Microvessel Density and the Expression of Vascular Growth Factor in Mice Tumor, Zhong Yao Cai，2011，（05）：676-679。

27.Sun Jian-ping,Tan Zhu-jun,Han Ya-li*，Reserch and Development of the Methods to Detection Apoptosis,Biotechnology Bulletin，2012，（01）：54-59。

28.Cao Fu-chun, Han Ya-li*，Effect of Eupolyphaga Fibrinolytic Protein on the VEGF and bFGF in HUVEC,A549,MCF-7 Cells，Lishizhen Medicine and Materia Medica Research，2011，（08）：1827-1829。

29.Wang Wei, Han Ya-li*,Purification and Biochemical Character of a Fibrinolytic Protein from Mylabris, Lishizhen Medicine and Materia Medica Research,2012,.23(3):550-552

30.Chen Ya-xiong, Tan Zhu-jun,Han Ya-li*,The fibrinolytic Activity and Properties of protein from Tenibrio Molitor, Lishizhen Medicine and Materia Medica Research,2011.22(1):169-171.

31.Han Ya-li,Cao Fu-chun,Yu Lei，The inhibitory effects and induction of fibrinolytic protein fromEupolyphaga sinensison the apoptosis of tumer S180 and H22 cells in mice，Chinese Pharmacological Bulletin，2011，（10）：1387-1391。

32.Wu Yan-ling, Tan Zhu-jun,Han Ya-li, Infrared Spectral Analysis and Enzymological Characteristic of Tenebrio Fibrinolytic Protein（TFP)，Lishizhen Medicine and Materia Medica Research，2011，22（9）：2061-2063.

Liu Hao,Han Ya-li*，The Antitumour EffectEupolyphaga Fibrinolytic Protein on S180 and H22 in vivo，Lishizhen Medicine and Materia Medica Research，2010，（09）：2140-2142。

33.LI Zi-wei, Han Ya-li,*,The Research of Thrombolytic and Hemolysis Effect from Eupolyphaga Fibrinolyric Protein and Its Inhibitory Effect on S180 Ascties Tumor of Mice，Zhong Yao Cai,，2010，（06）：859-863。

34.Li Xing-nuan, Han Ya-li*,Cloning and Expression of Eupolyphaga sinensis WalKer Fibrinolytic Protein cDNA in Pichia pastoris，Biotechnology Bulletin，2009，（11）：140-144。

35.Han Ya-li,Guo Wei,Li Xing-nuan，The inhibitory effects and immunoregulatory activity of the fibrinolytic protein fromEupolyphaga sinensisWalker(EFP) in vivo on H22 in mice,Chinese Pharmacological Bulletin，2009，25（07）：900-903。

36.Zhang Dong-mei, Han Ya-li*, The Inhibitory Effect of the Protein ofEupolyphaga sinensisWalker on Human Tongue Cancer Cell Line Tea-8113 in vitro,Lishizhen Medicine and Materia Medica Research，2009，（04）：778-779。

37.Chen Shao-peng,Han Ya-li*，Study on the antithrombotic effect of fibrinolytic proteins from Scolopendra subspinipes mutilans.Chinese Pharmacological Bulletin,2007，（08）：1088-1092。

38.Han Ya-li,Li Zhang-wei, Purification and Activity Calculated of Fibrinolyric Factors fromEupolyphaga sinensis,Zhong Yao Cai,29(8):765-767.

39.Xu Mei-yi,Han Ya-li,*。Separation ,Purification and Sepectrum Analysis of Tptal Flavonoids from Cercis chinensis，Zhong Yao Cai，2007，(10)：1252-1255。

40.Li Xing-nuan, Han Ya-li*. Antiangiogenesis of fibrinolytic protein fromEupolyphaga sinensisWalker.Acta Zoologica Sinica,2007, 53(1):135-142

41.Wei Guo, Ya-li Han,Extraction and Purification Groups fromEupolyphaga sinensisWalker inhibit Angiogenesis and Tumor Growth of the S180 Inoculated Mice,Chinese Journal of Cell Biology,2007,29(3):425-428.

42.Han Ya-li, Deng Rui-peng, Spectral Analysis and Study of the Microsome Cytochrome P450 Aromatase of Thais clvigera,Spectroscopy and Spectral Analysis,2006,26(1): 130-132.

43.Li Xing-nuan, Han Yali*,Effects of Tributyltin on DNA Damage of Gill Cell from Saccostrea cucullata,Acta Hydrobiologica Sinica,2005, 29(3): 336-339.

44.Deng Rui-peng, Han Ya-li*,A Study on Diferences of Cytochrome P450 Aromatase in female,male and Imposex samples of Thais clavigeras, Acta Hydrobiologica Sinica,2005,29(1):110-112.

45.Li Zhang-wei, Han Ya-li*，Study on protection of activity of endogenous enzymes system in imposex sample of Thais clavigera，Marine Environmental Science，200，（4）：36-38。

46.Deng Rui-peng ,Han Ya-li*,Tissue culture of oyster gills and the effects of TBYCL on cells activity,Marine Environmental Science,2004,23 (2):5-8.

47.Guan Yun-yan, Han Ya-li *, Effects on Karyotype of two species of thais and variations of chromosomen from imposex individuality,Marine Environmental Science,2004,23(4) :21-23.

48.Zhou Xiao-peng, Han Ya-li*, Application of RAPD on the study of imposex mechanism in Thais clavigera, Marine Environmental Science, 2004,23（4）：31-34.

49.Han Ya-li, Zhou Xiao-peng .The mechanism for tributyltin-induced imposex in mollusca,Journal of Shanhai Fisheries University,2003, 12(3):174-178.

50.Han Ya-li, Xiao Xiang, Studies of the Phentypic Character and Consanguinity of Isozymes in Species and Population, Hereditas,2002, 24(6) :670-674.